abstract：OBJECTIVES:To develop a simplified Therapeutic Intervention Scoring System (TISS) based on the TISS-28 items and to validate the new score in an independent database. DESIGN:Retrospective statistical analysis of a database and a prospective multicentre study. SETTING:Development in the database of the Foundation for ...

journal_title：Intensive care medicine

authors： Reis Miranda D,Moreno R,Iapichino G

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVES:To assess the markers of perfusion which best discriminate survivors from non-survivors of childhood sepsis and to compare the information derived from gastric tonometry with conventionally measured haemodynamic and laboratory parameters. DESIGN:Prospective clinical study of children with sepsis syndrome or...

journal_title：Intensive care medicine

authors： Duke TD,Butt W,South M

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:To study the influence of continuous administration of heparin on platelet function in intensive care patients. DESIGN:Prospective, serial investigation. SETTING:Clinical investigation on a surgical and neurosurgical intensive care unit in a university hospital. PATIENTS:The study included 45 patients: 15 ...

journal_title：Intensive care medicine

authors： Boldt J,Müller M,Rothe A,Lenzen P,Hempelmann G

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To examine the usefulness of preload indices obtained by transoesophageal echocardiography (TOE) for estimating stroke volume at various levels of cardiac index. DESIGN:Prospective clinical study. SETTING:Intensive care unit with surgical patients. PATIENTS:16 ventilated patients monitored via Swan-Ganz ca...

journal_title：Intensive care medicine

authors： Greim CA,Roewer N,Apfel C,Laux G,Schulte am Esch J

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:We tested the hypothesis that synchronization to patient effort during intermittent mandatory ventilation (SIMV), when compared to conventional unsynchronized intermittent mandatory ventilation (IMV), will decrease energy expenditure, as reflected by decreased oxygen consumption (VO2). DESIGN:We used a four-...

journal_title：Intensive care medicine

authors： Smith KM,Wahlig TM,Bing DR,Georgieff MK,Boros SJ,Mammel MC

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVES:To compare the effects of norepinephrine and dobutamine to epinephrine on hemodynamics, lactate metabolism, and gastric tonometric variables in hyperdynamic dopamine-resistant septic shock. DESIGN:A prospective, intervention, randomized clinical trial. SETTING:Adult medical/surgical intensive care unit in ...

journal_title：Intensive care medicine

authors： Levy B,Bollaert PE,Charpentier C,Nace L,Audibert G,Bauer P,Nabet P,Larcan A

更新日期：1997-03-01 00:00:00

abstract：:Pneumonia caused by herpes simplex virus type 1 (HSV1) is rare and occurs in severely immunosuppressed patients. HSV1 can be detected in bronchoalveolar lavage (BAL) from patients presenting with respiratory failure, but its direct effect on disease is difficult to prove. We demonstrate the causative role of HSV1 in t...

journal_title：Intensive care medicine

authors： François-Dufresne A,Garbino J,Ricou B,Wunderli W

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVES:Critically ill patients often develop anaemia which can be related to a number of factors. However, the exact causes of anaemia in many patients remain unexplained. We hypothesized that the relationship between erythropoietin (EPO) and haematocrit may be altered in critically ill patients. DESIGN:Serum conc...

journal_title：Intensive care medicine

authors： Rogiers P,Zhang H,Leeman M,Nagler J,Neels H,Mélot C,Vincent JL

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:To analyze the actual cost of pediatric intensive care and its different components, particularly the differences between various patient groups, with special reference to the variable cost and the elements included in it. DESIGN:Prospective, observational study. SETTING:Multidisciplinary 12-bed pediatric i...

journal_title：Intensive care medicine

authors： García S,Ruza F,Alvarado F,Madero R,Delgado MA,Dorao P,Frias M

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:Inhalation of nitric oxide (NO) can improve oxygenation and decrease mean pulmonary artery pressure (MPAP) in patients with the acute respiratory distress syndrome (ARDS). It is not known whether inhaled NO exerts a similar effect in hypoxemic patients with chronic obstructive pulmonary disease (COPD). DESIG...

journal_title：Intensive care medicine

authors： Blanch L,Joseph D,Fernández R,Mas A,Martinez M,Vallés J,Diaz E,Baigorri F,Artigas A

更新日期：1997-01-01 00:00:00

abstract：:We report a case of fatal septic shock, with hyperlactatemia and blood cultures positive for Streptococcus pneumoniae, in a 70-year-old patient. On two occasions (5 days, and 2 days before the patient's death), the relationship between oxygen delivery (DO2) and consumption (VO2) was examined in conjunction with two pr...

journal_title：Intensive care medicine

authors： Gallet D,Goudable J,Vedrinne JM,Viale JP,Annat G

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of minitracheotomy (MT) insertion for intratracheal oxygen insufflation (ITO2) on arterial blood gases and survival in patients with respiratory failure from chronic lung disease. DESIGN:Open, prospective clinical study. SETTING:A 12-bed medical intensive care unit in a non-universi...

journal_title：Intensive care medicine

authors： Andrivet P,Richard G,Viau F,Letinier JY,Darne C,Vu Ngoc C

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between the clinically evaluated depth of midazolam-induced sedation and the cardiac beat-to-beat variability (RR variability) in ICU patients in the intensive care unit (ICU). DESIGN:Prospective study. SETTING:ICU of a university hospital. PATIENTS:20 consecutive patients stu...

journal_title：Intensive care medicine

authors： Haberthür C,Lehmann F,Ritz R

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:To investigate the accuracy of eight different prognostic scores (Stiehm, Niklasson, Leclerc, Garlund, the MOC score, Tesero, the Glasgow Meningococcal Septicaemia Prognostic Score (GMSPS) and Tüyzüs) in the prediction of fatal outcome in meningococcal disease. DESIGN:Combined prospective and retrospective s...

journal_title：Intensive care medicine

authors： Derkx HH,van den Hoek J,Redekop WK,Bijlmer RP,van Deventer SJ,Bossuyt PM

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:To determine the relation of malnutrition and underlying diagnosis to the length of stay in the Intensive Care Unit (ICU) and to mortality after lung transplantation (LTX). DESIGN:Retrospective ICU chart review. SETTING:Cardiothoracic ICU in a University hospital. PATIENTS:Fifty-one consecutive patients wh...

journal_title：Intensive care medicine

authors： Plöchl W,Pezawas L,Artemiou O,Grimm M,Klepetko W,Hiesmayr M

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:The study was undertaken to determine if critically ill patients under mechanical ventilation could reactivate latent cytomegalovirus (CMV) in either lung or blood. DESIGN:Prospective study in critically ill patients was performed in a multidisciplinary intensive care unit in a university hospital. PATIENTS...

journal_title：Intensive care medicine

authors： Stéphan F,Méharzi D,Ricci S,Fajac A,Clergue F,Bernaudin JF

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:Evaluation of the distribution and antibiotic susceptibility of the aerobic gram-negative bacilli (AGNB) isolated from patients in intensive care units (ICU study). DESIGN AND SETTING:Microbiological study carried out in 1991 in 39 teaching hospitals. A standardized method was used to determine the minimum i...

journal_title：Intensive care medicine

authors： Jarlier V,Fosse T,Philippon A

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:To investigate the theoretical interactions between ventilator settings, tracheal gas insufflation (TGI), and alveolar ventilation. DESIGN:We derived differential equations governing compartmental volume changes in a one-compartment model of TGI-assisted ventilation and equations governing gas dilution in th...

journal_title：Intensive care medicine

authors： Hotchkiss JR Jr,Crooke PS 3rd,Marini JJ

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:The efficacy of interferon gamma therapy in reducing infection and improving outcome from infection in patients sustaining major injury was examined. DESIGN:Randomized double-blind placebo control trial SETTING:Nine level one university affiliated trauma centers in the United States. PATIENTS AND PARTICIPA...

journal_title：Intensive care medicine

authors： Dries DJ

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:To evaluate compliance with recommended patient-care practices for the prevention of hospital-acquired infections (HAI) in the intensive care unit (ICU). DESIGN:European descriptive survey by questionnaire mailed to all the directors of ICUs. PATIENTS AND PARTICIPANTS:A total of 1642 general ICUs with more ...

journal_title：Intensive care medicine

authors： Moro ML,Jepsen OB

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVE:To validate the TRISS method as an audit system on a group of patients with severe trauma admitted to an Italian general intensive care unit (ICU). DESIGN:Prospective, cohort study of consecutive admissions to the ICU. SETTING:A 6-bed general ICU in a 500-bed general hospital. PATIENTS:190 patients with se...

journal_title：Intensive care medicine

authors： Corbanese U,Possamai C,Casagrande L,Bordino P

更新日期：1996-09-01 00:00:00

abstract：:Although colitis is often seen in critically all patients who have received multiple broad-spectrum antibiotics, there are no reports describing severe sepsis as a result of Clostridium difficile infection. We describe three cases of severe sepsis with local intestinal Clostridium difficile infection as the only ident...

journal_title：Intensive care medicine

authors： Lowenkron SE,Waxner J,Khullar P,Ilowite JS,Niederman MS,Fein AM

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to identify risk factors and to describe epidemiological patterns for early-(EOB) and late-onset bacteremias (LOB) after trauma. DESIGN:A prospective study conducted on 141 consecutive trauma patients. SETTING:A general intensive care unit (ICU) of a university hospital. PATIENTS:...

journal_title：Intensive care medicine

authors： Antonelli M,Moro ML,D'Errico RR,Conti G,Bufi M,Gasparetto A

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:We investigated the effect of different levels of continuous positive airway pressure (CPAP) on the cricothyroid (CT; a tensor muscle of the vocal folds) and posterior cricoarytenoid (PCA; sole abductor muscle of the vocal folds) muscles in dogs. DESIGN:Prospective, controlled animal study. SUBJECTS:Nine m...

journal_title：Intensive care medicine

authors： Iwasaki H,Ohmori H,Sumita S,Yamauchi M,Namiki A

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:Inhalation of nitric oxide (NO) selectively dilates pulmonary vessels in well-ventilated regions. Prostaglandin F2 alpha (PGF2 alpha) is a vasoconstrictor and is reported to enhance hypoxic pulmonary vasoconstriction. The objective of this study was to examine whether the combination of intravenous PGF2 alph...

journal_title：Intensive care medicine

authors： Kobayashi H,Tanaka N,Winkler M,Zapol WM

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:To investigate the morphological changes in the liver in patients with organ failure and hyperbilirubinemia and to correlate them to the outcome. DESIGN:A case series prospective study. SETTING:Intensive care units of two general hospitals. PATIENTS:Twelve patients in organ failure with predominant hepatic...

journal_title：Intensive care medicine

authors： Douzinas EE,Vamvasakis E,Rigas K,Pitaridis M,Kittas C,Roussos C

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVE:Both serum levels of tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6) and blood lactate levels in patients with septic shock have been shown to correlate with prognosis. The aim of the study was to define the relative predictive value of these measures. PATIENTS:38 hospitalized patients with ...

journal_title：Intensive care medicine

authors： Marecaux G,Pinsky MR,Dupont E,Kahn RJ,Vincent JL

更新日期：1996-05-01 00:00:00

abstract：:We observed a 51-year-old woman who was admitted for severe amitriptyline overdose. Besides major cardiovascular complications, the patient developed severe hyperpyrexia with a central body temperature of more than 43 degrees C for 5 h. The patient died on day 3 from cardiocirculatory collapse and arrhythmias. Hyperth...

journal_title：Intensive care medicine

authors： Hantson P,Benaissa M,Clemessy JL,Baud FJ

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that the rate of degradation of exogenously administered albumin is faster with bolus administration than with continuous infusion and thus that a bolus administration is less efficacious in restoring blood albumin concentration (BAC) in the hypoalbuminemic critically ill pediatric pati...

journal_title：Intensive care medicine

authors： Greissman A,Silver P,Nimkoff L,Sagy M

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:To assess whether monitoring of bladder epithelial oxygen tension (BEOT) would provide an indication of regional (renal) organ perfusion in an exsanguination/fluid repletion animal model. DESIGN:Prospective non-randomized laboratory study. SETTING:Research laboratory. INTERVENTIONS:Eight anaesthetised, spo...

journal_title：Intensive care medicine

authors： Singer M,Millar C,Stidwill R,Unwin R

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:To measure the effects of rapid permissive hypercapnia on hemodynamics and gas exchange in patients with acute respiratory distress syndrome (ARDS). DESIGN:Prospective study. SETTING:18-bed, medical intensive care unit, university hospital. PATIENTS:11 mechanically ventilated ARDS patients. INTERVENTION:P...

journal_title：Intensive care medicine

authors： Thorens JB,Jolliet P,Ritz M,Chevrolet JC

更新日期：1996-03-01 00:00:00

abstract：:The case of an 11-year-old boy who suffered second and third degree burns to 78% of his body is reported. The large doses of morphine used as analgesia resulted in severe side effects: ventilatory dependence, impairment of gastrointestinal function and psychological disturbance. Intravenous lignocaine was added withou...

journal_title：Intensive care medicine

authors： Lyons B,Casey W,Doherty P,McHugh M,Moore KP

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVE:To study the pharmacokinetics and local tissue effects resulting from the intratracheal administration of preservative-free fentanyl. DESIGN:Prospective, randomized, blinded and controlled animal study. SETTING:University research laboratory. SUBJECTS:Eighteen adult male New Zealand rabbits. INTERVENTIONS...

journal_title：Intensive care medicine

authors： Irazuzta JE,Ahmed U,Gancayco A,Ahmed ST,Zhang J,Anand KJ

更新日期：1996-02-01 00:00:00

abstract：:We report a fatal case of a child presenting Reye's syndrome associated with a variety of arrhythmias and ischemia-like ST-T ECG changes. At autopsy, fatty infiltration and patchy myocytolysis were detected in sections of the heart. This case report emphasizes cardiac involvement in Reye's syndrome and the possible me...

journal_title：Intensive care medicine

authors： Sarti A,Cecchi F,Manetti A,Busoni P

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:To assess the effect of partial liquid ventilation with perfluorocarbons on hemodynamics and gas exchange in large pigs with induced acute lung injury (ALI). DESIGN:Randomized, prospective, double-control, experimental study. Experimental intensive care unit of a university. MATERIALS:Eighteen large pigs (5...

journal_title：Intensive care medicine

authors： Houmes RJ,Verbrugge SJ,Hendrik ER,Lachmann B

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:To clarify the risk of secondary exposure of medical staff to sarin vapor in the emergency room, and to warn emergency room staffs of the hazard. DESIGN:Retrospective observational survey. SETTING:Emergency department of a university hospital in a metropolitan area of Japan. PARTICIPANTS:Fifteen doctors tr...

journal_title：Intensive care medicine

authors： Nozaki H,Hori S,Shinozawa Y,Fujishima S,Takuma K,Sagoh M,Kimura H,Ohki T,Suzuki M,Aikawa N

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:Evaluation of low-level PEEP (5 cm H2O) and the two different CPAP trigger modes in the Bennett 7200a ventilator (demand-valve and flow-by trigger modes) on inspiratory work of breathing (Wi) during the weaning phase. DESIGN:Prospective controlled study. SETTING:The intensive care unit of a university hospi...

journal_title：Intensive care medicine

authors： Sydow M,Golisch W,Buscher H,Zinserling J,Crozier TA,Burchardi H

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:To assess the effects of the cyclooxygenase inhibitor diclofenac in a canine model of pulmonary occlusion and reperfusion of the left lower lobe (LLL). DESIGN:Twelve adult beagle dogs (13-17 kg) were randomly assigned to a control group (n = 6) and a diclofenac-treated group (n = 6). Animals in the treatment...

journal_title：Intensive care medicine

authors： Segiet W,Krieter H,Stieber C,Albrecht DM,van Ackern K

更新日期：1995-10-01 00:00:00

abstract：:As a result of the previous shortage of tools to assess objectively the overall physiological status of the respiratory system in infants and young children, it has been difficult to measure the degree of physiological disorder or the response to therapy in respiratory diseases such as BPD, the pediatric version of AR...

journal_title：Intensive care medicine

authors： Hammer J,Newth CJ

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:To compare some of the confirmatory investigations of brain death with clinical criteria in order to achieve the most sensitive and accurate diagnosis of brain death. DESIGN:All patients with isolated brain lesions and Glasgow Coma Scale (GCS) = 3 were subjected to neurological examination after ruling out h...

journal_title：Intensive care medicine

authors： Paolin A,Manuali A,Di Paola F,Boccaletto F,Caputo P,Zanata R,Bardin GP,Simini G

更新日期：1995-08-01 00:00:00